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Towards understanding molecular modes of probiotic action

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Author: Marco, M.L. · Pavan, S. · Kleerebezem, M.
Institution: TNO Kwaliteit van Leven
Source:Current Opinion in Biotechnology, 2, 17, 204-210
Identifier: 239186
doi: doi:10.1016/j.copbio.2006.02.005
Keywords: Biology · Biomedical Research · Cells · Consumer products · Food products · Genes · Health care · Animal models · Host effector molecules · Probiotic bacteria · Microorganisms · probiotic agent · bacterial colonization · bacterial strain · bacterial survival · bacterium adherence · dendritic cell · DNA microarray · follow up · food biotechnology · host resistance · human · immunomodulation · infection prevention · intestine flora · Lactobacillus acidophilus · Lactobacillus casei · nonhuman · nutrigenomics · priority journal · review · wild type · Animals · Humans · Intestinal Mucosa · Probiotics · Animalia · Bacteria (microorganisms)


The possibility that certain microorganisms might be beneficial to human health is highlighted by the numerous consumer products containing probiotic bacteria. Probiotics are typically administered in food that, following entry into the gastro-intestinal tract, results in measurable health-promoting effects. Although there is a growing list of health benefits provided by the consumption of probiotics, their precise mechanisms of action remain largely unknown. Recent molecular- and genomics-based studies are starting to provide insight into the ways probiotic bacteria sense and adapt to the gastro-intestinal tract environment. Complementary approaches using host cell in vitro systems together with animal models and human volunteers are revealing specific intestinal cell responses to probiotics. These studies should ultimately disclose the molecular mechanisms and pinpoint the bacterial and host effector molecules and pathways by which probiotics are able to modulate human health. © 2006 Elsevier Ltd. All rights reserved.