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Catch-up growth up to ten years of age in children born very preterm or with very low birth weight

Author: Knops, N.B.B. · Sneeuw, K.C.A. · Brand, R. · Hille, E.T.M. · Ouden, A.L. den · Wit, J.M. · Verloove-Vanhorick, S.P.
Type:article
Date:2005
Institution: TNO Kwaliteit van Leven
Source:BMC Pediatrics, 26, 5
Identifier: 277658
doi: doi:10.1186/1471-2431-5-26
Keywords: Health · Body height · Body mass · Catch up growth · Child growth · Female · Human · Major clinical study · Male · Netherlands · Newborn care · Postnatal development · Postnatal growth · Prematurity · Prognosis · School child · Small for date infant · Very low birth weight · Weight gain

Abstract

Background: Improved survival due to advances in neonatal care has brought issues such as postnatal growth and development more to the focus of our attention. Most studies report stunting in children born very preterm and/or small for gestational age. In this article we study the growth pattern of these children and aim to identify factors associated with postnatal catch-up growth. Methods: 1338 children born with a gestational age <32 weeks and/or a birth weight of <1500 grams were followed during a Dutch nationwide prospective study (POPS). Subgroups were classified as appropriate for gestational age and <32 weeks (AGA) or small for gestational age (<32 wks SGA and ≥32 wks SGA). Data were collected at different intervals from birth until 10 years for the 962 survivors and compared to reference values. The correlation between several factors and growth was analysed. Results: At 10 years the AGA children had attained normal height, whereas the SGA group demonstrated stunting, even after correction for target height (AGA: 0.0 SDS; SGA <32 wks: -0.29SDS and ≥32 wks: -0.13SDS). Catch-up growth was especially seen in the SGA children with a fast initial weight gain. BMI was approximately 1 SD below the population reference mean. Conclusion: At 10 years of age, children born very preterm AGA show no stunting. However, many children born SGA, especially the very preterm, show persistent stunting. Early weight gain seems an important prognostic factor in predicting childhood growth. © 2005 Knops et al; licensee BioMed Central Ltd.