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Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: Pooled analysis of prospective cohort studies

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Author: Zhang, X. · Albanes, D. · Beeson, W.L. · Brandt, P.A. van den · Buring, J.E. · Flood, A. · Freudenheim, J.L. · Giovannucci, E.L. · Goldbohm, R.A. · Jaceldo-Siegl, K. · Jacobs, E.J. · Krogh, V. · Larsson, S.C. · Marshall, J.R. · McCullough, M.L. · Miller, A.B. · Robien, K. · Rohan, T.E. · Schatzkin, A. · Sieri, S. · Spiegelman, D. · Virtamo, J. · Wolk, A. · Willett, W.C. · Zhang, S.M. · Smith-Warner, S.A.
Type:article
Date:2010
Institution: TNO Kwaliteit van Leven
Source:Journal of the National Cancer Institute, 11, 102, 771-783
Identifier: 360827
Keywords: Biology · Food and Chemical Risk Analysis

Abstract

BackgroundThe relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. MethodsWe investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. ResultsCompared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, Ptrend =. 68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, Ptrend =. 01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, Ptrend =. 91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P >. 20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P >. 05). ConclusionsDrinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study. The Author 2010. Published by Oxford University Press. © The Author 2010.