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Embryotoxicity and teratogenicity study with γ-cyclodextrin in rats

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Author: Waalkens-Berendsen, D.H. · Verhagen, F.J.J. · Bär, A.
Type:article
Date:1998
Source:Regulatory Toxicology and Pharmacology, 2, 27, 166-171
Identifier: 234418
doi: doi:10.1006/rtph.1998.1221
Keywords: Biology · gamma cyclodextrin · lactose · animal experiment · animal tissue · article · body weight · controlled study · dose response · embryotoxicity · female · fetus · fetus weight · fluid intake · food intake · male · nonhuman · oral drug administration · priority journal · rat · sexual behavior · teratogenicity · uterus weight · Animal Feed · Animals · Body Weight · Cyclodextrins · Drinking · Eating · Female · Fetal Viability · Fetus · gamma-Cyclodextrins · Gestational Age · Male · Pregnancy · Rats · Rats, Wistar · Teratogens · Weight Gain · Animalia · Solanum tuberosum

Abstract

The embryotoxicity/teratogenicity of γ-cyclodextrin (γ-CD) was examined in Wistar Crl:(WI)WU BR rats. γ-CD was fed at dietary concentrations of 0, 1.5, 5, 10, and 20% to groups of 25 pregnant female rats from day 0 to 21 of gestation. A comparison group received a diet with 20% lactose. The additions to the diet of γ-CD and lactose were made at the expense of pregelatinized potato starch. Body weight and food and water intake were recorded during the treatment period. The rats were killed on day 21 and examined for standard parameters of reproductive performance. The fetuses were examined for signs of toxic and teratogenic effects. Generally, γ-CD was well tolerated and no deaths occurred in any group. Weight gain and food consumption were similar in all groups during gestation, except for a slightly reduced food intake in the 20% γ-CD group from day 0 to 16. Water intake was similar in all γ-CD groups; in the lactose group, it was significantly higher than in the control group. Reproductive performance was not affected by the γ-CD treatment. Examination of the fetuses for external, visceral, and skeletal alterations did not reveal any fetotoxic, embryotoxic, or teratogenic effects of γ-CD. In conclusion, no adverse effects were observed at γ-CD intakes of up to about 20% of the diet (approximately 11 g/kg body wt/day). Chemicals/CAS: Cyclodextrins; gamma-cyclodextrin, 17465-86-0; gamma-Cyclodextrins; Teratogens