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Lack of inhibitory effects of beta-carotene, vitamin C, vitamin E and selenium on development of ductular adenocarcinomas in exocrine pancreas of hamsters

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Author: Appel, M.J. · Garderen-Hoetmer, A. van · Woutersen, R.A.
Type:article
Date:1996
Institution: Instituut CIVO-Toxicologie en Voeding TNO
Source:Cancer Letters, 2, 103, 157-162
Identifier: 83679
doi: doi:10.1016/0304-3835(96)04207-3
Keywords: Nutrition · Animals · Ascorbic Acid · beta Carotene · Body Weight · Carcinogens · Carcinoma, Ductal, Breast · Carotenoids · Cricetinae · Diet · Male · Mesocricetus · Nitrosamines · Organ Size · Pancreatic Neoplasms · Selenium · Vitamin E

Abstract

The effects of vitamins E and E, β-carotene and selenium on development of N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic tumours in hamsters were investigated. Dietary supplementation of vitamin C, alone as well as in combination with β-carotene resulted in consistently lower numbers of advanced ductular lesions. The differences with the controls, however, did not reach the level of statistical significance. β-carotene alone demonstrated no inhibitory effect on the development of (pre)neoplastic lesions in the pancreas. Vitamin E or Se, either alone or in combination, had no effect on the development of advanced ductular lesions in BOP-treated hamsters. Chemicals/CAS: Ascorbic Acid, 50-81-7; beta Carotene, 7235-40-7; Carcinogens; Carotenoids, 36-88-4; Nitrosamines; nitrosobis(2-oxopropyl)amine, 60599-38-4; Selenium, 7782-49-2; Vitamin E, 1406-18-4