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Efficacy, safety and novel targets in cardiovascular disease: advanced applications in APOE*3-Leiden.CETP mice

Author: Pouwer, M.G.
Publisher: Universiteit
Place: Leiden
Identifier: 875205
ISBN: 978-94-028-1639-6
Keywords: Atherosclerosis · Cholesterol · Lipoprotein metabolism · PFOA · PCSK9 · BCR-ABL1 Tyrosine kinase inhibitors · Cardiovascular safety · Oncostatin M · Cardiovascular Disease · Translational mouse models · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences


The thesis discussed several strategies that may contribute to further CVD risk reduction in the future. We described two novel lipid-lowering strategies, we unraveled (part of) the etiology of the cardiovascular safety issues of TKIs that are used for the treatment of CML, and we investigated the dose effects of PFOA on lipoprotein metabolism. Looking forward, we developed a novel mouse model that can be used for the study of diabetic macrovascular complications, and we evaluated the potential of OSM as novel target in CVD.