Excessive crying, often described as infantile colic, is the cause of 10% to 20% of all early pediatrician visits of infants aged 2 weeks to 3 months. Although usually benign and selflimiting, excessive crying is associated with parental exhaustion and stress. However, and underlying organic cause is found in less than 5% of these infants. In the majority of cases, treatment consists not of “curing the colic,” although usually it is possible to reduce crying, but of helping the parents to get through this challenging period in their baby’s development. The aims of this review are to discuss definition, etiology, and evaluate different treatment regimes in infants who cry excessively.