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The diagnostic work up of growth failure in secondary health care ; An evaluation of consensus guidelines

Author: Grote, F.K. · Oostdijk, W. · Muinck Keizer-Schrama, S.M.P.F. de · Dommelen, P. van · Buuren, S. van · Dekker, F.W. · Ketel, A.G. · Moll, H.A. · Wit, J.M.
Institution: TNO Kwaliteit van Leven
Source:BMC Pediatrics, 8
Identifier: 240794
doi: doi:10.1186/1471-2431-8-21
Article number: 21
Keywords: Health · Body height · Celiac disease · Child health care · Consensus development · Controlled study · Diagnostic procedure · Growth disorder · Health care delivery · Human · Laboratory test · Major clinical study · Medical record · Morbidity · Outpatient department · Patient referral · Pediatric ward · Practice guideline · Sensitivity and specificity · Short stature · Small for date infant · Blood · Clinical practice · Diagnosis, measurement and analysis · General hospital · Infant · Pituitary dwarfism · Standard · Statistics · University hospital · Utilization review · Adolescent · Body Height · Celiac Disease · Child · Child, Preschool · Dwarfism, Pituitary · Female · Growth Disorders · Guideline Adherence · Hospitals, General · Hospitals, University · Humans · Infant · Laboratory Techniques and Procedures · Male · Netherlands · Physician's Practice Patterns · Practice Guidelines as Topic · Referral and Consultation · Retrospective Studies · Turner Syndrome


Background: As abnormal growth might be the first manifestation of undetected diseases, it is important to have accurate referral criteria and a proper diagnostic work-up. In the present paper we evaluate the diagnostic work-up in secondary health care according to existing consensus guidelines and study the frequency of underlying medical disorders. Methods: Data on growth and additional diagnostic procedures were collected from medical records of new patients referred for short stature to the outpatient clinics of the general paediatric departments of two hospitals (Erasmus MC - Sophia Children's Hospital, Rotterdam and Spaarne Hospital, Haarlem) between January 1998 and December 2002. As the Dutch Consensus Guideline (DCG) is the only guideline addressing referral criteria as well as diagnostic work-up, the analyses were based on its seven auxological referral criteria to determine the characteristics of children who are incorrectly referred and the adequacy of workup of those who are referred. Results: Twenty four percent of children older than 3 years were inappropriately referred (NCR). Of the correctly referred children 74-88% were short corrected for parental height, 40-61% had a height SDS <-2.5 and 21% showed height deflection (Δ HSDS < -0.25/yr or Δ HSDS < -1). In none of the children a complete detailed routine diagnostic work up was performed and in more than 30% no routine laboratory examination was done at all. Pathologic causes of short stature were found in 27 children (5%). Conclusion: Existing guidelines for workup of children with suspected growth failure are poorly implemented. Although poorly implemented the DCG detects at least 5% pathologic causes of growth failure in children referred for short stature. New guidelines for referral are required with a better sensitivity and specificity, wherein distance to target height should get more attention. The general diagnostic work up for short stature should include testing for celiac disease in all children and for Turner syndrome in girls. © 2008 Grote et al; licensee BioMed Central Ltd.