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Molecular markers for osteoarthritis: The road ahead

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Author: Groot, J. de · Bank, R.A. · Tchetverikov, I. · Verzijl, N. · TeKoppele, J.M.
Type:article
Date:2002
Institution: Gaubius Instituut
Source:Current Opinion in Rheumatology, 5, 14, 585-589
Identifier: 236670
doi: doi:10.1097/00002281-200209000-00019
Keywords: Biology · Biomedical Research · biological marker · cartilage oligomeric matrix protein · chondroitin sulfate · collagen · collagen type 2 · cytokine · epitope · hyaluronic acid · keratan sulfate · matrix metalloproteinase · osteocalcin · proteoglycan · sialoprotein · tissue inhibitor of metalloproteinase · transforming growth factor beta1 · tumor necrosis factor receptor 2 · cross linking reagent · arthritis · articular cartilage · collagen synthesis · cross linking · disease course · inflammation · prognosis · review · synovium · extracellular matrix · genetic marker · genetics · metabolism · pathology · Collagen Type II · Cross-Linking Reagents · Extracellular Matrix · Genetic Markers · Matrix Metalloproteinases · Osteoarthritis · Proteoglycans · Support, Non-U.S. Gov't · Humans

Abstract

Osteoarthritis is a disabling joint disease that is characterized by the progressive destruction of articular cartilage. Diagnosis is based on clinical symptoms in combination with radiography, which is relatively insensitive and provides only an indication of accumulated damage. Alternative methods, such as molecular markers, are therefore needed that can quantitatively, reliably, and sensitively detect osteoarthritic changes in the joints at an early stage of the disease. Such molecular markers are essential for diagnosis, prognosis, and monitoring of disease progression and efficacy of therapy that is targeted at joint destruction. In addition, these markers are important for the development of new disease-modifying therapies. This concise review discusses the developments over the past 2 years in the field of molecular markers for osteoarthritis. © 2002 Lippincott Williams & Wilkins, Inc. Chemicals/CAS: cartilage oligomeric matrix protein, 161028-53-1; chondroitin sulfate, 9007-28-7, 9082-07-9; collagen, 9007-34-5; hyaluronic acid, 31799-91-4, 9004-61-9, 9067-32-7; keratan sulfate, 69992-87-6, 9056-36-4; osteocalcin, 136461-80-8; tissue inhibitor of metalloproteinase, 97837-28-0; Matrix Metalloproteinases, EC 3.4.24.-; Collagen Type II; Cross-Linking Reagents; Genetic Markers; Proteoglycans