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Salinomycin-induced polyneuropathy in cats: Morphologic and epidemiologic data

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Author: Linde-Sipman, J.S. van der · Inch, T.S.G.A.M. van den · Nes, J.J. van · Verhagen, H. · Kersten, J.G.T.M. · Beynen, A.C. · Plekkringa, R.
Type:article
Date:1999
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:Veterinary Pathology, 2, 36, 152-156
Identifier: 235328
Keywords: Nutrition · Cat · Peripheral nervous system · Polyneuropathy · Salinomycin · Toxic · salinomycin · animal cell · animal food · animal lameness · article · food analysis · food contamination · motor nerve · nerve degeneration · nonhuman · paralysis · peripheral nerve · polyneuropathy · sensory nerve · Animal Feed · Animals · Cat Diseases · Cats · Coccidiostats · Disease Outbreaks · Female · Food Contamination · Forelimb · Hindlimb · Ionophores · Lameness, Animal · Male · Netherlands · Peripheral Nerves · Peripheral Nervous System Diseases · Pyrans

Abstract

In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and kidney of affected cats revealed contamination with the ionophor salinomycin. Epidemiologic and clinical data were collected from 823 cats, or about 1% of the cats at risk. In 21 affected cats, postmortem examination was performed. The affected cats had acute onset of lameness and paralysis of the hindlimbs followed by the forelimbs. Clinical and pathologic examination indicated a distal polyneuropathy involving both the sensory at motor nerves.