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Induction of mutations in bacteriophage T7 by gamma-rays. No influence of the SOS repair pathway

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Author: Bleichrodt, J.F. · Roos-Verheij, W.S.D.
Institution: Medisch Biologisch Laboratorium TNO
Source:Mutation Research, 1, 72, 25-30
Identifier: 228848
Keywords: Biology · Animal experiment · Bacteriophage · DNA repair · Gamma radiation · Heredity · In vitro study · Bacteriophage lambda · DNA Repair · DNA, Viral · Dose-Response Relationship, Radiation · Gamma Rays · Mutation · Oxygen Consumption · T-Phages


Under conditions where the reversion of an amber mutant of bacteriophage ?? by ??-rays is enhanced by subjecting the irradiated phage to SOS repair, ??-ray-induced reversion of two T7 ambers is not influenced by this error-prone bacterial repair system. The survival of T7 ??-irradiated under anoxic conditions is somewhat enhanced by SOS repair, whereas the survival of phage irradiated under oxygen is not affected. Chemicals/CAS: DNA, Viral