Many contemporary work tasks are characterised by little or no physical activity. This pertains to the whole body as well as specific areas such as neck and shoulders. Too little whole body physical activity is generally known to increase the risk of chronic diseases like vascular disorders and diabetes. Low-intensity tasks of static nature are regarded as one of the risk factors of work related musculoskeletal disorders of neck and shoulders. TNO Quality of Life has developed recommendations for a healthy amount of physical activity at work, both for the whole body and the neck-/shoulder area. These recommendations are presented here, including their scientific basis.