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Transient hypothyroxinaemia associated with developmental delay in very preterm infants

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Author: Meijer, W.J. · Verloove-Vanhorick, S.P. · Brand, R. · Brande, J.L. van den
Institution: TNO Preventie en Gezondheid
Source:Archives of Disease in Childhood, 7, 67, 944-947
Identifier: 231749
Keywords: Thyroxine · Child · Child development · Female · Male · Major clinical study · Newborn · Prematurity · Preschool child · Psychomotor development · Thyroxine blood level · Very low birth weight · Child, Preschool · Developmental Disabilities · Follow-Up Studies · Human · Hypothyroidism · Infant · Infant, Low Birth Weight · Infant, Newborn · Infant, Premature · Logistic Models · Odds Ratio · Psychomotor Performance · Thyroxine


In 563 surviving very preterm (<32 weeks gestational age) and/or very low birthweight (<1500 g) infants the relationship between neonatal thyroxine concentration and psychomotor development at 2 years of age (corrected for preterm birth) was studied. A significant association was found between low neonatal thyroxine concentration and a negative score on the three milestones of development. These findings do not support the view that transient hypothyroxinaemia in preterm infants is harmless. Chemicals/CAS: thyroxine, 7488-70-2; Thyroxine, 7488-70-2