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Plasma annexin A5 level relates inversely to the severity of coronary stenosis

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Author: Tits, L.J.H. van · Heerde, W.L. van · Vleuten, G.M. van der · Graaf, J. de · Grobbee, D.E. · Vijver, L.P.L. van de · Stalenhoef, A.F. · Princen, H.M.
Type:article
Date:2007
Institution: TNO Kwaliteit van Leven
Source:Biochemical and Biophysical Research Communications, 3, 356, 674-680
Identifier: 239978
doi: doi:10.1016/j.bbrc.2007.03.020
Keywords: Biology · Biomedical Research · Angiography · Annexin A5 · Atherosclerosis · Cardiovascular diseases · Coronary disease · Coronary stenosis · Oxidized low-density lipoprotein · Oxidized phospholipids · biological marker · lipocortin 5 · oxidized low density lipoprotein · adult · aged · article · atherosclerosis · cardiovascular risk · controlled study · coronary artery obstruction · disease severity · female · human · lipid peroxidation · major clinical study · male · priority journal · protein blood level · risk assessment · risk factor · Aged · Aged, 80 and over · Annexin A5 · C-Reactive Protein · Carotid Arteries · Cohort Studies · Coronary Angiography · Coronary Stenosis · Humans · Lipoprotein(a) · Lipoproteins, LDL · Male · Middle Aged

Abstract

Exogenous radiolabeled annexin A5 is taken up by atherosclerotic tissue. We measured endogenous plasma annexin A5 and circulating oxidized low-density lipoprotein (oxLDL), a biochemical marker of atherosclerosis, in men with either severe angiographically determined coronary stenosis (n = 90) or no or only minor stenosis (n = 96). Men without history of cardiac disease or treatment and free of plaques in the carotid artery (by ultrasonography) were taken as controls (n = 87). Opposite to oxLDL, annexin A5 decreased at increasing severity of stenosis. OxLDL was lowest and annexin A5 was highest in controls. Percentage differences between groups were higher for annexin A5 than for oxLDL, and highest for oxLDL/annexin A5 ratio. The oxLDL/annexin A5 ratio is a better marker of the severity of coronary stenosis than oxLDL alone, may reflect the presence and extent of the atherosclerotic cardiovascular disease, and might prove useful for preclinical screening purposes. © 2007 Elsevier Inc. All rights reserved.