Two modified Mg-Al hydrotalcites (MHTs), (MHT-pAB and MHT-NO2) were incorporated into mortar (with different w/c ratios) in two different ways: (1) as one of the mixing components in bulk mortar; (2) as part of cement paste coating of the reinforcing steel. Accelerated chloride migration, cyclic wetting-drying and diffusion tests were performed to investigate their effect on reinforcement corrosion. The results indicated that MHTs could be promising alternatives for preventing chloride-induced corrosion when an appropriate dosage is adopted and applied in a proper way, particularly, replacing 5% mass of cement by MHT-pAB in bulk mortar or as a coating of reinforcing steel (MHT-pAB/MHT-NO2 to replace 20% mass of cement). The effect of MHT-pAB on time-to-corrosion initiation (TTC) of reinforcing steel was estimated using the DuraCrete model. It was found that the incorporation of 5% MHT-pAB in bulk mortar led to a more than double TTC relative to reference mortar without MHTs.