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The use of Stabilyte® plasma may cause changes in pH in the assay of some fibrinolysis analytes and might effect results

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Author: Meijer, P. · Ham, F. van der · Kluft, C.
Institution: Gaubius Laboratory TNO Preventie en Gezondheid
Source:Fibrinolysis, SUPPL. 2, 10, 155-157
Identifier: 233526
doi: doi:10.1016/S0268-9499(96)80075-0
Keywords: Biology · assay · clinical article · conference paper · controlled study · fibrinolysis · human · normal human · ph · plasma · priority journal · standardization


The use of Stabilyte® plasma in the Coaliza® t-PA, Coaliza® PAI-1 and Enzygnost® PAP micro was evaluated. For PAI-1 antigen no, for t-PA antigen only small differences were observed between measurements in citrate and Stabilyte® plasma. For PAP-complexes significant lower (72%) results were obtained when Stabilyte® plasma was applied. This is the result of a lower pH during the first step of the test in comparison with citrated plasma.