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Thrombolytic properties in a rabbit jugular vein thrombosis model of a tissue-type plasminogen activator mutant lacking the growth factor- and kringle 1-domains

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Author: Emeis, J.J. · Verheijen, J.H.
Type:article
Date:1992
Institution: Instituut voor Verouderings- en Vaatziekten Onderzoek TNO
Source:Annals of the New York Academy of Sciences, 667, 421-423
Identifier: 232009
doi: doi:10.1111/j.1749-6632.1992.tb51642.x
Keywords: Biology · Alpha 2 antiplasmin · Alteplase · Fk 2p · Gowth factor · Plasminogen · Unclassified drug · Animal experiment · Animal model · Blood clot lysis · Conference paper · Dose response · Dose time effect relation · Drug efficacy · Fibrinogen blood level · Intravenous drug administration · Mutant · Nonhuman · Protein domain · Spectrophotometry · Vein thrombosis · Animal · Comparative Study · Fibrinolysis · Infusions, Intravenous · Injections, Intravenous · Jugular Veins · Metabolic Clearance Rate · Rabbits · Recombinant Proteins · Thrombosis · Tissue Plasminogen Activator · Animalia · Oryctolagus cuniculus

Abstract

Chemicals/CAS: Recombinant Proteins; Tissue Plasminogen Activator, EC 3.4.21.68