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Fungal peroxidases : molecular aspects and applications

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Author: Conesa, A. · Punt, P.J. · Hondel, C.A.M.J.J.
Type:article
Date:2002
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:Journal of Biotechnology, 2, 93, 143-158
Identifier: 42150
doi: DOI:10.1016/S0168-1656(01)00394-7
Keywords: Biology · Amino Acid Sequence · Binding Sites · Biotechnology · Catalysis · Fungi · Molecular Sequence Data · Peroxidases · Recombinant Proteins · Sequence Homology · Substrate Specificity

Abstract

Peroxidases are oxidoreductases that utilize hydrogen peroxide to catalyze oxidative reactions. A large number of peroxidases have been identified in fungal species and are being characterized at the molecular level. In this manuscript we review the current knowledge on the molecular aspects of this type of enzymes. We present an overview of the research efforts undertaken in deciphering the structural basis of the catalytic properties of fungal peroxidases and discuss molecular genetics and protein homology aspects of this enzyme class. Finally, we summarize the potential biotechnological applications of these enzymes and evaluate recent advances on their expression in heterologous systems for production purposes. © 2002 Elsevier Science B.V. All rights reserved. Molecular Sequence Numbers: GENBANK: AJ300448; Chemicals/CAS: Peroxidases, EC 1.11.1.-; Recombinant Proteins