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Assessment of protein allergenicity on the basis of immune reactivity: Animal models

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Author: Kimber, I. · Dearman, R.J. · Penninks, A.H. · Knipples, L.M.J. · Buchanan, R.B. · Hammerberg, B. · Jackson, H.A. · Helm, R.M.
Source:Environmental Health Perspectives, 8, 111, 1125-1130
Identifier: 237204
Keywords: Toxicology · Toxicology and Applied Pharmacology · Allergy · Dog · Hazard identification · IgE · IgG · Immunogenicity · Mouse · Rat · Risk assessment · Swine · food allergen · protein · allergenicity · animal experiment · biotechnology · DNA modification · dog · food allergy · food intake · food safety · immunoreactivity · methodology · microorganism · nonhuman · priority journal · retrospective study · review · swine · world health organization · Administration, Oral · Animals · Dietary Proteins · Disease Models, Animal · Dogs · Food Hypersensitivity · Humans · Infusions, Parenteral · Mice · Mice, Inbred BALB C · Peanut Hypersensitivity · Rats · Risk Assessment · Swine · Animalia · Canis familiaris · Sus scrofa


Because of the public concern surrounding the issue of the safety of genetically modified organisms, it is critical to have appropriate methodologies to aid investigators in identifying potential hazards associated with consumption of foods produced with these materials. A regent panel of experts convened by the Food and Agriculture Organization and World Health Organization suggested there is scientific evidence that using data from animal studies will contribute important information regarding the allergenicity of foods derived from biotechnology. This view has given further impetus to the development of suitable animal models for allergenicity assessment. This article is a review of what has been achieved and what still has to be accomplished regarding several different animal models. Progress made in the design and evaluation of models in the rat, the mouse, the dog and in swine is reviewed and discussed.