This document provides a full description of the new version of EXIOMOD (EXtended Input-Output MODel). "Extended" refers to the fact that EXIOMOD can extend the standard Input-Output (IO) analysis in two main directions: (1) to Computational General Equilibrium model (CGEM or CGE model) analysis, and (2) to specific topics such as environmental impacts, energy, or transport. EXIOMOD 2.0 is based on a flexible modular approach that allows for using different economic models (e.g. IO versus CGE model, Walrasian versus Keynesian closure), and for adapting the specification and refinement of the model to the subject under investigation (e.g. changing the regional and sectorial segmentation, activating specific blocks). This document also present several typical applications of EXIOMOD based on the IO and CGE models: calculation of consumption-based indicators, decomposing price and volume effects, policy scenarios to reach 2050 resource efficiency targets.