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Different human gut models reveal the distinct fermentation patterns of arabinoxylan versus inulin

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Author: Abbeele, P. van den · Venema, K. · Wiele, T. van de · Verstraete, W. · Possemiers, S.
Type:article
Date:2013
Source:Journal of Agricultural and Food Chemistry, 41, 61, 9819-9827
Identifier: 482979
doi: doi:10.1021/jf4021784
Keywords: Biology · Bifidobacterium adolescentis · Bifidobacterium longum · Bowel · Fructans · High specificity · Human gut microbiota · Intestine · Microflora · Polysaccharides · Volatile fatty acids · Bacteria · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences

Abstract

Different in vitro models have been developed to assess how food compounds affect the human gut microbiota. Using two such models (SHIME(R) and TIM-2), we compared how long-chain arabinoxylan (LC-AX), a wheat-derived potentially prebiotic fiber, and inulin (IN), a well-established prebiotic compound, modulate SCFA production and bifidobacteria composition. While both the SHIME and TIM-2 differ in experimental design, they both demonstrated that LC-AX and IN specifically increased the health-promoting metabolites propionate and butyrate, respectively. Furthermore, LC-AX stimulated Bifidobacterium longum, while IN stimulated other bifidobacteria including Bifidobacterium adolescentis. The SHIME experiment also revealed that effects of LC-AX were more persistent during the 2-week wash-out period. These results confirm a recent in vivo study, during which humanized rats were treated with the same LC-AX/IN. In conclusion, results from different human gut models suggest that, besides IN, LC-AX are promising prebiotic candidates with high specificity toward Bifidobacterium longum and a selective propionate increase. © 2013 American Chemical Society.