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Oligofructose stimulates calcium absorption in adolescents

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Author: Heuvel, E.G.H.M. van den · Muys, T. · Dokkum, W. van · Schaafsma, G.
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:American Journal of Clinical Nutrition, 3, 69, 544-548
Identifier: 234961
Keywords: Nutrition · Double stable- isotope technique · Male adolescents · Nondigestible oligosaccharides · Oligofructose · True calcium absorption · Calcium · Fructose · Oligosaccharide · Stable isotope · Adolescent · Calcium absorption · Calcium metabolism · Clinical research · Clinical trial · Controlled clinical trial · Controlled study · Crossover procedure · Dietary intake · Double blind procedure · Drug absorption · Human · Human experiment · Intravenous drug administration · Male · Normal human · Oral drug administration · Randomized controlled trial · Urinalysis · Urinary excretion · Administration, Oral · Adolescent · Analysis of Variance · Calcium · Cross-Over Studies · Double-Blind Method · Fructose · Humans · Injections, Intravenous · Intestinal Absorption · Male · Sucrose


Background: In rats, nondigestible oligosaccharides stimulate calcium absorption. Recently, this effect was also found in human subjects. Objective: The objective of the study was to investigate whether consumption of 15 g oligofructose/d stimulates calcium absorption in male adolescents. Design: Twelve healthy, male adolescents aged 14-16 y received, for 9 d, 15 g oligofructose or sucrose (control treatment) daily over 3 main meals. The treatments were given according to a randomized, double-blind, crossover design, separated by a 19-d washout period. On the 8th day of each treatment period, 44Ca was given orally with a standard breakfast containing ≃200 mg Ca. Within half an hour after administration of 44Ca, 48Ca was administered intravenously. Fractional calcium absorption was computed from the enrichment of 44Ca:43Ca and 48Ca:43Ca in 36-h urine samples, which was measured by inductively coupled plasma mass spectrometry. Results: An increase in true fractional calcium absorption (%) was found after consumption of oligofructose (mean difference ± SE of difference: 10.8 ± 5.6; P < 0.05, one sided). The results are discussed in relation to the methods used. Conclusion: Fifteen grams of oligofructose per day stimulates fractional calcium absorption in male adolescents.