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Pooled analysis of prospective cohort studies on height, weight and breast cancer risk

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Author: Brandt, P.A. van den · Spiegelman, D. · Yaun, S-S. · Adami, H-O. · Beeson, L. · Folsom, A.R. · Fraser, G. · Goldbohm, R.A. · Graham, S. · Kushi, L. · Marshall, J.R. · Miller, A.B. · Rohan, T. · Smith-Warner, S.A. · Speizer, F.E. · Willett, W.C. · Wolk, A. · Hunter, D.J.
Type:article
Date:2000
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:American Journal of Epidemiology, 6, 152, 514-527
Identifier: 56881
doi: doi:10.1093/aje/152.6.514
Keywords: Nutrition · Body height · Body weight · Breast neoplasms · Prospective studies · Adult · Aged · Anthropometric parameters · Body height · Body mass · Breast cancer · Cancer risk · Clinical trial · Controlled clinical trial · Controlled study · Female · Human · Major clinical study · Multicenter study · Postmenopause · Premenopause · Weight reduction · Adult · Aged · Aged, 80 and over · Body Height · Body Weight · Breast Neoplasms · Cohort Studies · Female · Humans · Middle Aged · Multivariate Analysis · Postmenopause · Premenopause · Prospective Studies · Regression Analysis · Risk Factors

Abstract

The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases. In multivariate analyses controlling for reproductive, dietary, and other risk factors, the pooled relative risk (RR) of breast cancer per height increment of 5 cm was 1.02 (95% confidence interval (Cl): 0.96, 1.10) in premenopausal women and 1.07 (95% Cl: 1.03, 1.12) in postmenopausal women. Body mass index (BMI) showed significant inverse and positive associations with breast cancer among pre- and postmenopausal women, respectively; these associations were nonlinear. Compared with premenopausal women with a BMI of less than 21 kg/m2, women with a BMI exceeding 31 kg/m2 had an RR of 0.54 (95% Cl: 0.34, 0.85). In postmenopausal women, the RRs did not increase further when BMI exceeded 28 kg/m2; the RR for these women was 1.26 (95% Cl: 1.09, 1.46). The authors found little evidence for interaction with other breast cancer risk factors. Their data indicate that height is an independent risk factor for postmenopausal breast cancer; in premenopausal women, this relation is less clear. The association between BMI and breast cancer varies by menopausal status. Weight control may reduce the risk among postmenopausal women.