Objective: To determine the effect of moderate alcohol intake on probability of conception. Design: Prospective cohort study. Setting: Normal healthy women enrolled in an artificial donor insemination program. Patients: Women starting artificial donor insemination for the very first time were selected. Interventions: Alcohol exposure was measured through a self- administered questionnaire at intake of study. Main Outcome Measure: A first positive pregnancy test as indicative for conception. Results: Women with moderate alcohol intake had a slightly higher, though not significant, probability of conception compared with nondrinkers (Hazard Ratio 1.20; 95% confidence interval 0.90 to 1.60). Conclusion: Moderate alcohol intake has no negative impact on female fecundity.