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A case-cohort study on prostate cancer risk in relation to family history of prostate cancer

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Author: Schuurman, A.G. · Zeegers, M.P.A. · Goldbohm, R.A. · Brandt, P.A. van den
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:Epidemiology, 2, 10, 192-195
Identifier: 234973
Keywords: Nutrition · Age · Family history · Prospective case-cohort study · Prostate cancer risk · Adult · Aged · Cancer risk · Cohort analysis · Controlled study · Family history · Human · Major clinical study · Male · Rostate cancer · Aged · Cohort Studies · Humans · Middle Aged · Multivariate Analysis · Netherlands · Prostatic Neoplasms


We investigated the risk of prostate cancer in relation to a family history of prostate cancer in 58,279 men ages 55-69 years. We found 704 incident cases after 6.3 years of follow-up. Rate ratios and 95% confidence intervals for having an affected vs nonaffected father and brother were, respectively 1.44 (0.80-2.58) and 5.57 (1.61-19.26). We found no evidence for an increasing risk with an increasing percentage of affected family members. The associations we observed were stronger for cases diagnosed before age 70 compared with cases diagnosed after age 70 and for advanced compared with localized tumors.