Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·
 

Non-invasive measurement of brain damage in a primate model of multiple sclerosis

Publication files not online:

Author: T Hart, B.A. · Vogels, J. · Bauer, J. · Brok, H.P.M. · Blezer, E.
Type:article
Date:2004
Institution: TNO Voeding
Source:Trends in Molecular Medicine, 2, 10, 85-91
Identifier: 237600
doi: doi:10.1016/j.molmed.2003.12.008
Keywords: Biology Health · Analytical research · myelin · allergic encephalomyelitis · brain injury · chemometric analysis · demyelination · diagnostic imaging · human · immunopathology · marmoset · multiple sclerosis · neurologic disease · neuropathology · non invasive measurement · nonhuman · nuclear magnetic resonance imaging · nuclear magnetic resonance spectroscopy · pattern recognition · positron emission tomography · proton nuclear magnetic resonance · review · urinalysis · white matter · X ray analysis · Animals · Animals, Outbred Strains · Antigens, CD · Biological Markers · Brain · Callithrix · CD4-Positive T-Lymphocytes · Chronic Disease · Demyelinating Diseases · Disease Models, Animal · Encephalomyelitis, Autoimmune, Experimental · Genes, MHC Class II · Humans · Magnetic Resonance Imaging · Magnetic Resonance Spectroscopy · Mice · Multiple Sclerosis · Myelin Basic Proteins · Myelin-Associated Glycoprotein · T-Lymphocytes, Cytotoxic · Th2 Cells · Animalia · Callithrix · Callithrix jacchus · marmosets · Primates · Rodentia

Abstract

Early recognition of whether a product has potential as a new therapy for treating multiple sclerosis (MS) relies upon the quality of the animal models used in the preclinical trials. The promising effects of new treatments in rodent models of experimental autoimmune encephalomyelitis (EAE) have rarely been reproduced in patients suffering from MS. EAE in outbred marmoset monkeys, Callithrix jacchus, is a valid new model, and might provide an experimental link between EAE in rodent models and human MS. Using magnetic resonance imaging techniques similar to those used in patients suffering from MS pathological abnormalities in the brain, white matter of the animal can be visualized and quantified. Moreover, NMR spectroscopy, in combination with pattern recognition, offers an advanced uroscopic technique for the identification of biomarkers of inflammatory demyelination.