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Retinoid (vitamin A) metabolism : a review

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Author: Hendriks, H.F.J.
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:European Journal of Clinical Nutrition, suppl. 3, 50, 2-6
Identifier: 84028
Keywords: Nutrition · Carboxylic Ester Hydrolases · Humans · Intestines · Liver · Receptors, Cell Surface · Receptors, Retinoic Acid · Retinoids · Tretinoin · Vitamin A · Metabolism · Overview · Proteins


Objective and conclusion: An overview is given of our understanding of the uptake and metabolism of retinoids. The mechanisms underlying retinol uptake by organs and tissues are still unsettled. The retinol-binding proteins CRBP I and CRBP II appear to play an essential role in retinyl ester hydrolysis and formation and in retinoic acid formation. Chemicals/CAS: Carboxylic Ester Hydrolases, EC 3.1.1.-; Receptors, Cell Surface; Receptors, Retinoic Acid; Retinoids; retinol binding protein receptor; retinyl esterase, EC 3.1.1.-; Tretinoin, 302-79-4; Vitamin A, 11103-57-4