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Neurological symptoms among Sri Lankan farmers occupationally exposed to acetylcholinesterase-inhibiting insecticides

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Author: Smit, L.A.M. · Wendel- de Joode, B.N. van · Heederik, D. · Peiris-John, R.J. · Hoek, W. van der
Type:article
Date:2003
Source:American Journal of Industrial Medicine, 3, 44, 254-264
Identifier: 237255
doi: doi:10.1002/ajim.10271
Keywords: Health Chemistry · Food and Chemical Risk Analysis · Acetylcholinesterase inhibition · IPM · Neurological symptoms · Pesticide exposure · Sri Lanka · acetylcholinesterase · insecticide · adult · agricultural worker · article · cholinesterase inhibition · controlled study · enzyme activity · female · human · integrated pest management · intoxication · major clinical study · male · neurologic disease · occupational exposure · questionnaire · Sri Lanka · symptomatology · Acetylcholinesterase · Adult · Agriculture · Cholinesterase Inhibitors · Female · Humans · Insecticides · Male · Middle Aged · Nervous System Diseases · Occupational Exposure · Prevalence · Sri Lanka

Abstract

Background: In many agricultural districts in Sri Lanka, pesticide poisoning is a leading cause of death. This study aims to evaluate the impact of pesticide use on Sri Lankan farmers' health. Methods: A total of 260 subjects were surveyed in both a low and a high exposure period. Acetylcholinesterase activity was measured and data on symptoms were collected with questionnaires. Results: Twenty-four percent of surveyed farmers had suffered at least once from acute pesticide poisoning. Farmers showed significantly more inhibition of cholinesterase activity than controls. Acute symptoms indicative for exposure to cholinesterase-inhibiting pesticides were associated with farming and a higher degree of cholinesterase suppression (more than 13% inhibition). Integrated Pest Management (IPM) training seemed to result in less insecticide use, and less cholinesterase inhibition. Conclusions: Our results suggest that occupational acetylcholinesterase-inhibiting insecticide exposures have a negative impact on Sri Lankan farmers' health. Overall reduction in pesticide use seems the best option to protect farmers from the adverse effects of pesticides. © 2003 Wiley-Liss, Inc.