Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·
 

Systems biology, connectivity and the future of medicine

Publication files not online:

Author: Greef, J. van der
Type:article
Date:2005
Institution: TNO Kwaliteit van Leven
Source:IEE Proceedings Systems Biology, 4, 152, 174-178
Identifier: 238849
doi: doi:10.1049/ip-syb:20050034
Keywords: Biology · Analytical research · Disease progression · Disease system fingerprints · Diseases · Drug perturbations · Drugs · Medicine · Patient treatment · Reversed-pharmacology · Systems biology · Systems pathology · Systems pharmacology · Systems-based combinatorial-therapies approach · Biology · Diseases · Drug therapy · Pathology · Pharmacokinetics · Disease system fingerprints · Pharmacology · Systems biology · Drug products · amlodipine plus atorvastatin · berberine · biological marker · fluticasone propionate plus salmeterol · ginseng extract · glibenclamide plus metformin · article · asthma · bioinformatics · biostatistics · cardiovascular disease · clinical protocol · disease course · drug design · drug industry · drug research · human · hypercholesterolemia · in vivo study · medicine · metabolic syndrome X · methodology · molecular biology · non insulin dependent diabetes mellitus · nonhuman · quality control · quality of life · Cell Physiology · Drug Design · Models, Biological · Pharmaceutical Preparations · Pharmacology · Pharmacology, Clinical · Systems Biology · Panax ginseng

Abstract

The concept of systems-based strategies in medicine is emerging, with systems pathology guiding an understanding of the multidimensional aspects of disease system fingerprints and systems pharmacology providing insight into dynamic system responses upon (multiple) drug perturbations. Knowledge of the changes of system characteristics during disease progression creates a framework for the design of novel combinatorial treatment strategies. Such a systems-based, combinatorial-therapies approach readdresses the value of the synergistic actions of components of treatments based on natural products and highlights new methodology to study multidimensional intervention via reversed-pharmacology. © IEEE, 2005.