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Osteopontin levels and increased disease activity in relapsing-remitting multiple sclerosis patients

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Author: Vogt, M.H.J. · Floris, S. · Killestein, J. · Knol, D.L. · Smits, M. · Barkhof, F. · Polman, C.H. · Nagelkerken, L.
Source:Journal of Neuroimmunology, 1-2, 155, 155-160
Identifier: 238039
doi: doi:10.1016/j.jneuroim.2004.06.007
Keywords: Disease activity · Relapsing-remitting multiple sclerosis · gadolinium · clinical article · controlled study · disease activity · disease exacerbation · female · longitudinal study · male · multiple sclerosis · nuclear magnetic resonance imaging · protein blood level · Adult · Central Nervous System · Cytokines · Disease Progression · Humans · Magnetic Resonance Imaging · Middle Aged · Multiple Sclerosis, Relapsing-Remitting · Osteopontin · Predictive Value of Tests · Recurrence · Sialoglycoproteins · Up-Regulation


Osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within multiple sclerosis (MS) lesions. Recently, we demonstrated that OPN plasma levels were elevated in active relapsing-remitting (RR) MS patients. In this longitudinal study, a trend was observed for OPN serum levels in relation to clinical exacerbations. Moreover, OPN protein levels were significantly elevated 1 month prior to increase of gadolinium (Gd)-enhancing lesion number, whereas no relation was observed between OPN levels and increase in Gd-enhancing lesion volume. Although no robust relation between OPN and disease activity was observed, these data suggest that OPN levels are elevated prior to increased disease activity in RR MS patients. © 2004 Elsevier B.V. All rights reserved. Chemicals / CAS: gadolinium, 7440-54-2; osteopontin, 106441-73-0; Cytokines; Osteopontin, 106441-73-0; SPP1 protein, human; Sialoglycoproteins