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Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies

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Author: Männistö, S. · Yaun, S.S. · Hunter, D.J. · Spiegelman, D. · Adami, H.O. · Albanes, D. · Brandt, P.A. van den · Buring, J.E. · Cerhan, J.R. · Colditz, G.A. · Freudenheim, J.L. · Fuchs, C.S. · Giovannucci, E. · Goldbohm, R.A. · Harnack, L. · Leitzmann, M. · McCullough, M.L. · Miller, A.B. · Rohan, T.E. · Schatzkin, A. · Virtamo, J. · Willett, W.C. · Wolk, A. · Zhang, S.M. · Smith-Warner, S.A.
Type:article
Date:2007
Institution: TNO Kwaliteit van Leven
Source:American Journal of Epidemiology, 3, 165, 246-255
Identifier: 239840
doi: doi:10.1093/aje/kwk009
Keywords: Health · Food and Chemical Risk Analysis · Carotenoids · Cohort studies · Colonic neoplasms · Colorectal neoplasms · Diet · Meta-analysis · Rectal neoplasms · alpha carotene · beta carotene · beta cryptoxanthin · carotenoid · lutein plus zeaxanthin · lycopene · cancer · carotenoid · cohort analysis · diet · etiology · health risk · multivariate analysis · adolescent · adult · article · cancer incidence · cancer risk · carcinogenesis · carcinogenic activity · child · cohort analysis · colon cancer · colorectal cancer · confidence interval · diet supplementation · female · follow up · food intake · human · major clinical study · male · multivariate analysis · questionnaire · rectum cancer · risk assessment · sex difference · statistical significance · Carotenoids · Cohort Studies · Colorectal Neoplasms · Diet · Europe · Female · Humans · Incidence · Male · Multivariate Analysis · North America · Proportional Hazards Models · Risk · Eurasia · Europe · North America

Abstract

Dietary carotenoids have been hypothesized to protect against epithelial cancers. The authors analyzed the associations between intakes of specific carotenoids (alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein + zeaxanthin, and lycopene) and risk of colorectal cancer using the primary data from 11 cohort studies carried out in North America and Europe. Carotenoid intakes were estimated from food frequency questionnaires administered at baseline in each study. During 6-20 years of follow-up between 1980 and 2003, 7,885 incident cases of colorectal cancer were diagnosed among 702,647 participants. The authors calculated study-specific multivariate relative risks and then combined them using a random-effects model. In general, intakes of specific carotenoids were not associated with colorectal cancer risk. The pooled multivariate relative risks of colorectal cancer comparing the highest quintile of intake with the lowest ranged from 0.92 for lutein + zeaxanthin to 1.04 for lycopene; only for lutein + zeaxanthin intake was the result borderline statistically significant (95% confidence interval: 0.84, 1.00). The associations observed were generally similar across studies, for both sexes, and for colon cancer and rectal cancer. These pooled data did not suggest that carotenoids play an important role in the etiology of colorectal cancer. Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health. All rights reserved.