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Dietary supplementation of different doses of NUTRIOSE®FB, a fermentable dextrin, alters the activity of faecal enzymes in healthy men

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Author: Heuvel, E.G.H.M. van den · Wils, D. · Pasman, W.J. · Saniez, M.H. · Kardinaal, A.F.M.
Institution: TNO Kwaliteit van Leven
Source:European Journal of Nutrition, 7, 44, 445-451
Identifier: 238751
doi: doi:10.1007/s00394-005-0552-0
Keywords: Health · Biomedical Research · α-glucosidase · β-glucosidase · Dextrin · NUTRIOSE®FB · alpha glucosidase · beta glucosidase · dextrin · maltodextrin · nutriose · placebo · adult · article · clinical trial · controlled clinical trial · controlled study · crossover procedure · diet supplementation · digestion · dose response · double blind procedure · enzyme activity · enzyme assay · feces · feces analysis · fermentation · fiber · gastrointestinal tract · human · male · multiple drug dose · normal human · parallel design · randomized controlled trial · wheat · Adult · beta-Glucosidase · Colon · Cross-Over Studies · Dextrins · Dietary Carbohydrates · Dietary Fiber · Dietary Supplements · Dose-Response Relationship, Drug · Double-Blind Method · Feces · Fermentation · Glucosidases · Humans · Male · Middle Aged · Triticum aestivum


Background: It is well documented that fermentation of carbohydrates that escape digestion exert several effects supposed to be beneficial for (colonic) health, including an increase in stool volume, a shorter intestinal transit time, production of short chain fatty acids and a decrease of colonic pH (Kritchevsky 1988). NUTRIOSE®FB is a dextrin that is not completely hydrolysed and absorbed in the small intestine, due to many α-1.6 linkages and the presence of non-digestible glucoside linkages (e. g. α-1.2 and α-1.3). To be beneficial for 'colonic' health effective NUTRIOSE®FB must reach the cecum in some form. Aim of the study: To estimate how much non digested NUTRIOSE®FB is fermented and to determine the fibrelike effect of the wheat dextrin NUTRIOSE ®FB by analysing enzymatic activity in faeces. Methods: In a randomized, double-blind,multiple dose, placebo-controlled, combined cross-over and parallel trial, 20 healthy men (age 31.7 ± 9.1 yrs; BMI 24.5 ± 2.9 kg •m-2 received different treatments. One group of ten subjects consumed on top of their diet 10, 30 and 60 g daily of NUTRIOSE ®FB or maltodextrin (placebo). The other group of 10 subjects consumed 15, 45 and 80 g daily. Each dose was consumed for 7 days. On the last two days of each of the 7-day period, faeces were collected in which the enzymatic activity and NUTRIOSE®FB residue were analysed. Results: As expected, the faecal residue of NUTRIOSE®FB non-linearly increased with the dose of NUTRIOSE®FB to approximately 13% of 80 g/d. Compared with the placebo, 30, 45, 60 and 80 g/d of NUTRIOSE®FB increased the concentration of α-glucosidase significantly. All daily doses of NUTRIOSE®FB (10 g/d to 80 g/d) led to significant changes in concentration of β-glucosidase. Conclusions: The small amount of the residue of NUTRIOSE®FB in the faeces suggests that approximately 87% or more of NUTRIOSE®FB is digested or fermented in the gastrointestinal tract. Fermentation of NUTRIOSE®FB led to an increased faecal concentration of α- and β-glucosidase. © Steinkopff Verlag 2005.