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The radial immunodiffusion assay for plasma Histidine-rich Glycoprotein (HRG) based on a polyclonal antibody, shows a different specificity towards the two variants of a common amino acid polymorphism

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Author: Hennis, B.C. · Hoffmann, J.J.M.L. · Kluft, C.
Type:article
Date:1996
Institution: Gaubius Laboratory Haemostasis Division, Department of Clinical Laboratories, Catharina Hospital, Eindhoven, Netherlands TNO Preventie en Gezondheid
Source:Fibrinolysis, SUPPL. 2, 10, 133-134
Identifier: 233518
Keywords: Biology · amino acid · glycoprotein · histidine rich glycoprotein · polyclonal antibody · unclassified drug · conference paper · controlled study · genetic polymorphism · human · immunoassay · immunodiffusion · priority journal · risk factor · thrombosis

Abstract

Recently, two molecular weight forms of Histidine-rich Glycoprotein have been described which explain 59% of the variation in plasma HRG levels. Here, we demonstrate that this can partly be ascribed to a difference in specificity of the immuno assay for HRG towards the two alleles of the polymorphism.