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Quality of life and self-esteem in children treated for idiopathic short stature

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Author: Theunissen, N.C.M. · Kamp, G.A. · Koopman, H.M. · Zwinderman, K.A.H. · Vogels, T. · Wit, J.-M.
Institution: TNO Preventie en Gezondheid
Source:Journal of Pediatrics, 5, 140, 507-515
Identifier: 280307
doi: doi:10.1067/mpd.2002.123766
Keywords: Human growth hormone · Body growth · Body height · Child · Clinical article · Clinical trial · Controlled clinical trial · Controlled study · Hormonal therapy · Idiopathic disease · Multicenter study · Patient satisfaction · Quality of life · Questionnaire · Randomized controlled trial · Self concept · Self esteem · Short stature · Social adaptation · social status · Analysis of Variance · Body Height · Child · Child, Preschool · Female · Growth Hormone · Humans · Linear Models · Male · Netherlands · Prospective Studies · Quality of Life · Self Concept


Objective: Changes in health-related quality of life (HRQOL) and self-esteem were studied in children with idiopathic short stature (ISS) participating in a study on the effect of growth hormone treatment. Study design: Prepubertal children (n = 36) with ISS were randomly assigned to a treatment or control group. Children with ISS, their parents, and the pediatrician completed HRQOL and self-esteem questionnaires 3 times in 2 years. Results: At the start, children with ISS did not have lower scores than the norm population, except for social functioning HRQOL. The pediatrician reported an improvement of HRQOL in the treatment group, the parents reported no change, and the children in the treatment group reported the same, or sometimes even worse, HRQOL or self-esteem than the control group. Changes related to the child's satisfaction with height and hardly to growth itself. Conclusion: The assumption that growth hormone treatment improves HRQOL in children with ISS could not be supported in this study. Chemicals/CAS: Growth Hormone, 9002-72-6