Many contemporary work tasks, e.g. at an office workplace, are characterised by physical inactivity and by long periods of uninterrupted sitting. These characteristics increase the risk of several health problems, among others obesity, cardiovascular disorders, diabetes, cancer, musculoskeletal disorders of lower back, neck and shoulders, and lower limb problems. Noteworthy is that the health risks associated with the sedentary character of work cannot be fully compensated by physical exercise in leisure time. Recommendations and various interventions to prevent physical inactivity and diminish sedentary time at the workplace have been developed. This article describes the health risks, recommendations and some of the interventions.