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The effect of ACTH analogues on motor behavior and visual evoked responses in rats

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Author: Wolthuis, O.L. · Wied, D. de
Institution: Medisch Biologisch Laboratorium TNO Chemisch Laboratorium TNO
Source:Pharmacology Biochemistry and Behavior, 3, 4, 273-278
Identifier: 228089
Keywords: Biology · Amphetamine · Corticotropin · Corticotropin derivative · Gallamine triethiodide · Alertness · Brain cortex · Brain depth electrode · Brain depth recording · Electroretinography · Evoked visual response · Motor activity · Rat · Structure activity relation · Subcutaneous drug administration · theoretical study · Animal · Corticotropin · Electroretinography · Evoked Potentials · Male · Motor Activity · Photic Stimulation · Rats · Time Factors


Averaged visual evoked responses (VER) in cortical area 17 were recorded one hour after the administration of 7-l-phe ACTH(4-10) or 7-d-phe ACTH(4-10) to artificially ventilated rats, paralysed with gallamine. In addition, the effects of these peptides on spontaneous motor behavior were analyzed. The results show that the latencies of all VER components remain unchanged and the amplitudes of the primary VER were unaffected. Measured at a wide variety of light intensities, however, the amplitudes of the VER after discharge were significantly and very similarly diminished by both peptides, the effect of 7-l-phe ACTH(4-10) being somewhat stronger than that of 7-d-phe ACTH(4-10). These results support the notion, advanced by others, that these peptides have an effect on a CNS vigilance regulating system, yet do not explain the reported opposite effects on active avoidance behavior of the two related peptides. The effects appear specific since spontaneous motor behavior, as index of changes in generalized arousal, is unaffected by these two peptides. Chemicals/CAS: amphetamine, 1200-47-1, 139-10-6, 156-34-3, 2706-50-5, 300-62-9, 51-62-7, 60-13-9, 60-15-1; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; gallamine triethiodide, 65-29-2; Corticotropin, 9002-60-2