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The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays

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Author: Vinken, M. · Doktorova, T. · Ellinger-Ziegelbauer, H. · Ahr, H.-J. · Lock, E. · Carmichael, P. · Roggen, E. · Delft, J. van · Kleinjans, J. · Castell, J. · Bort, R. · Donato, T. · Ryan, M. · Corvi, R. · Keun, H. · Ebbels, T. · Athersuch, T. · Sansone, S.-A. · Rocca-Serra, P. · Stierum, R. · Jennings, P. · Pfaller, W. · Gmuender, H. · Vanhaecke, T. · Rogiers, V.
Type:article
Date:2008
Institution: TNO Kwaliteit van Leven
Source:Mutation Research - Reviews in Mutation Research, 3, 659, 202-210
Identifier: 240979
doi: doi:10.1016/j.mrrev.2008.04.006
Keywords: Biology · Physiological Sciences · carcinoGENOMICS · Chemical carcinogenesis · FP6 project · Genomics · Genotoxic carcinogen · Metabolomics · Metabonomics · Model compounds · Non-genotoxic carcinogen · REACH · Selection criteria · 1,3 butadiene · 2 nitrofluorene · 2,3,7,8 tetrachlorodibenzo para dioxin · aflatoxin B1 · alkanone · arsenate sodium · asbestos · benzo[a]pyrene · bromodichloromethane · cadmium derivative · chemical compound · chloroprene · chlorothalonil · dichromate sodium · dimethylnitrosamine · isobutyl nitrite · methapyrilene · monuron · nifedipine · ochratoxin · phenobarbital · phorbol 13 acetate 12 myristate · piperonyl butoxide · pirinixic acid · potassium bromate · s (1,2 dichlorovinyl)cysteine · streptozocin · tolbutamide · unindexed drug · vinyl chloride · carcinogenicity · genomics · human · in vitro study · medical information · medical research · model · nonhuman · priority journal · review · screening · Animal Testing Alternatives · Carcinogenicity Tests · European Union · Gene Expression Profiling · Genomics · Hazardous Substances · International Cooperation · Toxicogenetics · Animalia

Abstract

Recent changes in the European legislation of chemical-related substances have forced the scientific community to speed up the search for alternative methods that could partly or fully replace animal experimentation. The Sixth Framework Program project carcinoGENOMICS was specifically raised to develop omics-based in vitro screens for testing the carcinogenic potential of chemical compounds in a pan-European context. This paper provides an in-depth analysis of the complexity of choosing suitable reference compounds used for creating and fine-tuning the in vitro carcinogenicity assays. First, a number of solid criteria for the selection of the model compounds are defined. Secondly, the strategy followed, including resources consulted, is described and the selected compounds are briefly illustrated. Finally, limitations and problems encountered during the selection procedure are discussed. Since selecting an appropriate set of chemicals is a frequent impediment in the early stages of similar research projects, the information provided in this paper might be extremely valuable. Crown Copyright © 2008.