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Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces postprandial blood glucose excursions in type 2 diabetic men

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Author: Manders, R.J. · Koopman, R. · Sluijsmans, W.E. · Berg, R. van den · Verbeek, K. · Saris, W.H. · Wagenmakers, A.J. · Loon, L.J. van
Type:article
Date:2006
Institution: TNO Kwaliteit van Leven
Source:Journal of Nutrition, 5, 136, 1294-1299
Identifier: 239261
Keywords: Biology · Analytical research · Amino acids · Insulin · Postprandial glucose · Type 2 diabetes · amino acid · carbohydrate · glucose · insulin · leucine · metformin · protein hydrolysate · sulfonylurea · amino acid blood level · area under the curve · article · body mass · controlled study · demography · glucose blood level · human · ingestion · insulin blood level · insulin like activity · insulin response · male · non insulin dependent diabetes mellitus · Administration, Oral · Amino Acids · Beverages · Blood Glucose · Body Mass Index · Body Size · Diabetes Mellitus, Type 2 · Diabetic Diet · Humans · Leucine · Male · Middle Aged · Postprandial Period · Protein Hydrolysates · Reference Values

Abstract

This study examined postprandial plasma insulin and glucose responses after co-ingestion of an insulinotropic protein (Pro) hydrolysate with and without additional free leucine with a single bolus of carbohydrate (Cho). Male patients with long-standing Type 2 diabetes (n = 10) and healthy controls (n = 10) participated in 3 trials in which plasma glucose, insulin, and amino acid responses were determined after the ingestion of beverages of different composition (Cho: 0.7 g/kg carbohydrate, Cho+Pro: 0.7 g/kg carbohydrate with 0.3 g/kg protein hydrolysate, or Cho+Pro+Leu: 0.7 g/kg carbohydrate, 0.3 g/kg protein hydrolysate and 0.1 g/kg free leucine). Plasma insulin responses [expressed as area under the curve (AUC)] were 141 and 204% greater in patients with Type 2 diabetes and 66 and 221% greater in the controls in the Cho+Pro and Cho+Pro+Leu trials, respectively, compared with those in the Cho trial (P < 0.05). The concomitant plasma glucose responses were 15 and 12% lower in the patients with Type 2 diabetes and 92 and 97% lower in the control group in the Cho+Pro and Cho+Pro+Leu trials, respectively, compared with those in the Cho trial (P < 0.05). Plasma leucine concentrations correlated with the insulin response in all subjects (r = 0.43, P < 0.001). We conclude that co-ingestion of a protein hydrolysate with or without additional free leucine strongly augments the insulin response after ingestion of a single bolus of carbohydrate, thereby significantly reducing postprandial blood glucose excursions in patients with long-standing Type 2 diabetes. © 2006 American Society for Nutrition.