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Glucagon receptors: Are they present on human blood cells?

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Author: Hinsbergh, V.W.M. van · Nooijen, W.J. · Kempen, H.J.M.
Institution: Gaubius instituut TNO
Source:Hormone and Metabolic Research, 2, 14, 65-68
Identifier: 229232
Keywords: drug receptor · glucagon receptor · insulin i 125 · radioisotope · blood and hemopoietic system · endocrine system · erythrocyte · glucagon i 125 · glucagon i 127 · human cell · in vitro study · leukocyte · monocyte · normal human · Animal · Blood Cells · Erythrocytes · Glucagon · Human · Liver · Lymphocytes · Monocytes · Rats · Receptors, Cell Surface · Receptors, Glucagon


Binding of glucagon to and its degradation by human mononuclear leukocytes and erythrocytes was investigated. Labeled glucagon binds to these cells, but can be displaced only by unlabeled glucagon at pharmacologically high concentrations. It is concluded that glucagon binding to human blood cells does not represent receptors of physiological importance and is of no value to the determination of glucagon sensitivity in man. Chemicals/CAS: Glucagon, 9007-92-5; Receptors, Cell Surface; Receptors, Glucagon