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On-line solid phase extraction-gas chromatography-cryotrapping-infrared spectrometry for the trace-level determination of microcontaminants in aqueous samples

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Author: Hankemeier, T · Hooijschuur, E. · Vreuls, R.J.J. · Brinkman, U.A.Th. · Visser, T.
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:HRC Journal of High Resolution Chromatography, 21 p., 341-346
Identifier: 41087
doi: doi:10.1002/(SICI)1521-4168(19980601)21:6<341::AID-JHRC341>3.0.CO;2-V
Keywords: Nutrition · Chemistry · Gas chromatography · Infrared spectrometry · Large-volume on-column injection · Microcontaminants · Open-split interface · Solid-phase extraction · Chemical analysis · Cryoprecipitation · Gas chromatography · Solid phase extraction · Water contamination


A large-volume on-column GC-cryotrapping-IR system was developed for injections of up to 100 μl of organic extracts. Considerable reduction of the solvent-and-water background and enhanced analyte detectability was achieved by using an open-split interface between the GC column and the IR detector and improving the leak-tightness of the system. The system was combined with solid-phase extraction to yield on-line SPE-GC-IR. With this set-up, sample volumes of only 20 ml sufficed to detect, and identify, microcontaminants in tap and surface water at the 0.1-1 μg/L level. Detection limits were on the order of 15 ng/L for tap water when using appropriate functional-group chromatograms. Or, in other words, SPE-GC-IR is a suitable technique for the screening of environmental water samples for functional groups, i.e. classes of compounds, of interest.