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Prediction of in vivo developmental toxicity of all‑trans‑retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

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Author: Louisse, J. · Bosgra, S. · Blaauboer, B.J. · Rietjens, Y.M.C.M. · Verwei, M.
Source:Reproductive Toxicology, 11p.
Identifier: 506928
doi: doi:10.1007/s00204-014-1289-4
Keywords: Toxicology · All-trans-retinoic acid · Developmental toxicity · In vitro-in vivo extrapolation · Physiologically based kinetic modeling · Reverse dosimetry · Solid phase microextraction · Food and Nutrition · Healthy Living · Life Triskelion BV · RAPID - Risk Assessment Products in Developmentv ARF - Analytical Research (Food) · ELSS - Earth, Life and Social Sciences TNO Bedrijven