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Acute inhalation toxicity study of ammonia in rats with variable exposure periods

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Author: Appelman, L.M. · Berge, W.F. ten · Reuzel, P.G.J.
Type:article
Date:1982
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:American Industrial Hygiene Association Journal, 9, 43, 662-665
Identifier: 229288
Keywords: Nutrition · Ammonia · Adverse drug reaction · Animal experiment · Dose response · Drug response · Drug toxicity · Epidemiology · Inhalation · Inhalational drug administration · Intoxication · Mortality · Respiratory system · Animal · Dose-Response Relationship, Drug · Female · Lethal Dose 50 · Male · Rats · Rats, Inbred Strains · Regression Analysis · Sex Factors · Support, Non-U.S. Gov't · Time Factors

Abstract

The acute inhalation toxicity of ammonia was examined in rats using various exposure concentrations and exposure periods. Groups of male and female rats were exposed to dynamic atmospheres containing different concentrations of ammonia for 10, 20, 40 or 60 min. The aim of the study was to establish the relationship between exposure concentration and exposure period and mortality. The correlation between exposure concentration (c), exposure period (t) and mortality rate, expressed in probits was found to be Probit = 2.30 1n [c(2.02) x t] - 47.8. The following LC50 values for ammonia were calculated: 10min LC50 : 28,130 mg/m3 air (40,300 ppm); 20 min LC50 : 19,960 mg/m3 (28,595 ppm); 40 min LC50 : 14,170 mg/m3 air (20,300 ppm); 60 min LC50 : 11,590 mg/m3 air (16,600 ppm). Chemicals/CAS: ammonia, 14798-03-9, 51847-23-5, 7664-41-7; Ammonia, 7664-41-7