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ADEM en het risico op het ontwikkelen van MS bij kinderen [ADEM and the risk of developing of MS with children]

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Author: Ketelslegers, I.A. · Boon, M. · Pereira, R.R. · Hintzen, R.Q. · Catsman-Berrevoets, C.E.
Type:article
Date:2009
Institution: TNO Kwaliteit van Leven
Source:Tijdschrift voor Kindergeneeskunde, 2, 77, 66-72
Identifier: 241454
Keywords: Health · Immunoglobulin · Methylprednisolone · Prednisone · Chronic disease · Clinical feature · Diagnostic test · Differential diagnosis · Disease course · Human · Incidence · Multiple sclerosis · Postvaccinal encephalitis · Prognosis · Rare disease · Review · Risk assessment

Abstract

Acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS) in children are relatively rare and the exact incidence is still unknown. There is great variability in clinical presentation and disease course. It is yet unclear which clinical and biological parameters can predict a chronic disease course and progression to multiple sclerosis. The diagnostic difficulties in distinguishing ADEM, MS and related disorders will be discussed. A review of the differential diagnosis, diagnostic tests, treatment and prognosis is given.