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Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma

Author: Dijk, B.A.C. van · Schouten, L.J. · Oosterwijk, E. · Hulsbergen van de · Kaa, C.A. · Kiemeney, L.A.L.M. · Goldbohm, R.A. · Schalken, J.A. · Brandt, P.A. van den
Type:article
Date:2006
Institution: TNO Kwaliteit van Leven
Source:British Journal of Cancer, 3, 95, 374-377
Identifier: 239420
doi: doi:10.1038/sj.bjc.6603281
Keywords: Health · Food and Chemical Risk Analysis · Cigarette smoking · Cohort study · Renal cell carcinoma · The Netherlands · Von Hippel-Lindau gene mutations · adenine · cytosine · guanine · thymine · adult · aged · article · cigarette smoking · clear cell carcinoma · cohort analysis · dose response · female · follow up · gene · gene mutation · human · human tissue · kidney carcinoma · major clinical study · male · Netherlands · nucleic acid base substitution · priority journal · risk factor · von hippel lindau gene · Aged · Carcinoma, Renal Cell · Cohort Studies · Female · Humans · Japan · Kidney Neoplasms · Male · Middle Aged · Multivariate Analysis · Mutation · Risk Factors · Smoking · Von Hippel-Lindau Tumor Suppressor Protein

Abstract

We investigated whether smoking is associated with mutations in the Von Hippel-Lindau (VHL) gene in 337 cases of sporadic renal cell carcinoma (RCC) among 120 852 people followed for 11.3 years; the findings suggest that smoking causes RCC independently of VHL gene mutations. © 2006 Cancer Research. Chemicals / CAS: adenine, 22177-51-1, 2922-28-3, 73-24-5; cytosine, 71-30-7; guanine, 69257-39-2, 73-40-5; thymine, 65-71-4; Von Hippel-Lindau Tumor Suppressor Protein, EC 6.3.2.19