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Prevalence and independent risk factors for hearing loss in NICU infants

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Author: Hille, E.T.M. · Straaten, H.L.M. van · Verkerk, P.H. · Straaten, I. van · Verkerk, P. · Hille, E. · Baerts, W. · Bunkers, C. · Smink, E. · Elburg, R. van · Kleine, M. de · Kok, J.H. · Ilsen, A. · Visser, D. · Steiner, K. · Vries, L.S. de · Weisglas-Kuperus, N. · Sprij, A. · Lopriori, E. · Brokx, J. · Gavilanes, D. · Geven, W. · Bos, A.
Institution: TNO Kwaliteit van Leven
Source:Acta Paediatrica, International Journal of Paediatrics, 8, 96, 1155-1158
Identifier: 240101
doi: doi:10.1111/j.1651-2227.2007.00398.x
Keywords: Health · Hearing screening · NICU population · Risk factors · Assisted ventilation · Birth weight · Craniofacial malformation · Disease severity · Familial disease · Hyperbilirubinemia · Intrauterine infection · Major clinical study · Newborn · Newborn intensive care · Ototoxicity · Perinatal asphyxia · Prevalence · Syndrome · Asphyxia Neonatorum · Evoked Potentials, Auditory, Brain Stem · Gestational Age · Hearing Loss · Humans · Infant, Newborn · Infant, Premature · Infant, Very Low Birth Weight · Intensive Care Units, Neonatal · Neonatal Screening · Netherlands · Respiration, Artificial · Time Factors


Aim: To determine the prevalence and independent relationship between hearing loss and risk factors in a representative neonatal intensive care unit (NICU) population. Methods: Automated auditory brainstem response (AABR) hearing screening has been introduced since 1998 in the Dutch NICUs. After a second AABR failure, diagnostic ABR was used to establish diagnosis of hearing loss. Newborns who died before the age of 3 months were excluded. In the present study only the NICU infants who were born with a gestational age <30 weeks and/or a birth weight <1000 g between October 1, 1998 and January 1, 2002 were included. Risk factors included in the study were familial hearing loss, in utero infections, craniofacial anomalies, birth weight <1500g, hyperbilirubinemia, ototoxic medications, cerebral complications, severe birth asphyxia, assisted ventilation ≥5 days and syndromes. Results: A nationwide cohort of 2186 newborns were included. Mean gestational age was 28.5 weeks (SD 1.6) and mean birth weight was 1039 g (SD 256). Prevalence of uni- or bilateral hearing loss was 3.2% (71/2186; 95% CI 2.6-4.1). Multivariate analysis revealed that the only independent risk factors for hearing loss were severe birth asphyxia (OR 1.7; 95% CI 1.0-2.7) and assisted ventilation ≥5 days (OR 3.6; 95% CI 2.1-6.0). Conclusion: The prevalence of hearing loss in a representative NICU population was 3.2%. Independent risk factors for hearing loss were severe birth asphyxia and assisted ventilation ≥5 days. © 2007 The Author(s).