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Investigating the role of natural phyto-oestrogens on bone health in postmenopausal women

Author: Valtueña, S. · Cashman, K. · Robins, S.P. · Cassidy, A. · Kardinaal, A. · Branca, F.
Type:article
Date:2003
Source:British Journal of Nutrition, SUPPL. 1, 89
Identifier: 237117
Keywords: Health Biology · Physiological Sciences · Clinical trials · Isoflavones · Menopause · acid phosphatase tartrate resistant isoenzyme · alkaline phosphatase bone isoenzyme · biochemical marker · collagen aminopeptide · collagen c peptide · collagen derivative · deoxypyridinoline · isoflavone · osteocalcin · phytoestrogen · procollagen c propeptide · procollagen n propeptide · pyridinoline · sialoprotein · soybean protein · unclassified drug · estrogen · isoflavone derivative · plant medicinal product · bone density · bone metabolism · bone mineral · bone remodeling · bone strength · bone turnover · clinical trial · diet supplementation · diet therapy · dietary intake · evidence based medicine · genetic variability · human · medical decision making · menopausal syndrome · nonhuman · ossification · osteoporosis · outcomes research · patient compliance · patient monitoring · patient selection · physical activity · postmenopause · review · short course therapy · chemistry · controlled clinical trial · diet · female · methodology · middle aged · postmenopause osteoporosis · randomized controlled trial · soybean · treatment outcome · Glycine max · Diet · Estrogens, Non-Steroidal · Female · Humans · Isoflavones · Middle Aged · Osteoporosis, Postmenopausal · Phytoestrogens · Plant Preparations · Randomized Controlled Trials · Research Design · Soybeans · Treatment Outcome

Abstract

Research on the bone effects of natural phyto-oestrogens after menopause is at a relatively early stage. Published studies are few, difficult to compare and often inconclusive, due in part to design weaknesses. Currently, many questions remain to be answered including to what extent a safe daily intake may prevent postmenopausal bone loss. These questions can only be addressed by conducting well-planned, randomised clinical trials that take into consideration present knowledge in the oestrogen, phyto-oestrogen and bone fields. This review is intended to provide hints for critical decision-making about the selection of subjects, type of intervention, suitable outcome measures and variables that need to be controlled.