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Evidence for the occurrence of a fast-acting inhibitor for tissue-type plasminogen activator in human plasma

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Author: Verheijen, J.H. · Chang, G.T.G. · Kluft, C.
Institution: Gaubius Instituut TNO
Source:Thrombosis and Haemostasis, 3, 51, 392-395
Identifier: 229582
Keywords: plasminogen activator · blood and hemopoietic system · human · inhibitor · plasma · Chromatography, Affinity · Electrophoresis, Polyacrylamide Gel · Glycoproteins · Human · Iodine Radioisotopes · Kinetics · Molecular Weight · Plasminogen Activators · Plasminogen Inactivators


Human plasma contains a fast-acting t-PA inhibitor, which is not identical with ??2-antiplasmin or ??2-macroglobulin. The concentration of this inhibitor in normal plasma is highly variable, much lower than that of known plasma protease inhibitors, and in the range of physiologically occurring plasma concentrations of t-PA (0-2 IU/ml). The inhibitor binds to concanavalin A-Sepharose, is rather stable when heated, is not precipitated in euglobulin fractions and probably does not originate from platelets. The inhibitor seems to form a 190 Kd complex with t-PA. The relation between this plasma inhibitor and the recently discovered endothelial cell inhibitor is not yet clear. Chemicals/CAS: plasminogen activator, 9039-53-6; Glycoproteins; Iodine Radioisotopes; Plasminogen Activators, EC 3.4.21.-; Plasminogen Inactivators