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Effects of Perinatal Exposure to PCBs on Neuropsychological Functions in the Rotterdam Cohort at 9 Years of Age

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Author: Vreugdenhil, H.J.I. · Emmen, H.H. · Mulder, P.G.H. · Weisglas-Kuperus, N.
Type:article
Date:2004
Institution: TNO Voeding
Source:Neuropsychology, 1, 18, 185-193
Identifier: 237563
doi: doi:10.1037/0894-4105.18.1.185
Keywords: Health Packaging · Analytical research · polychlorinated biphenyl · article · breast feeding · breast milk · child · cohort analysis · comparative study · controlled study · decision making · drug effect · environmental exposure · female · human · infant · intelligence · lactation · learning · major clinical study · male · Netherlands · neuropsychological test · neuropsychology · neurotoxicity · nonparametric test · pollutant · pregnancy · prenatal exposure · priority journal · psychomotor performance · reaction time · regression analysis · response time · scoring system · short term memory · vision · Breast Feeding · Child · Cohort Studies · Decision Making · Environmental Pollutants · Female · Humans · Intelligence · Male · Maternal Exposure · Memory, Short-Term · Milk, Human · Netherlands · Neuropsychological Tests · Polychlorinated Biphenyls · Pregnancy · Prenatal Exposure Delayed Effects · Psychomotor Performance · Reaction Time · Regression Analysis · Statistics, Nonparametric · Verbal Learning · Visual Perception

Abstract

PCBs are known for their neurotoxic properties, especially on the developing brain. To increase insight into the neurotoxic effects of PCB exposure, the authors studied the effects of perinatal exposure to environmental levels of these compounds on different neuropsychological domains. In 9-year-old children of the Rotterdam PCB-dioxin cohort, higher prenatal PCB levels were associated with longer response times (RTs), more variation in RTs, and lower scores on the Tower of London (TOL; Shallice, 1982). A longer breast-feeding duration was associated with lower TOL scores and with better spatial organizational skills. There was some evidence of negative effects of lactational exposure to PCBs on scores on the TOL.