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Modulation of pancreatic carcinogenesis by antioxidants

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Author: Woutersen, R.A. · Appel, M.J. · Garderen van -Hoetmer, A.
Type:article
Date:1999
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:Food and Chemical Toxicology, 9-10, 37, 981-984
Identifier: 235143
doi: doi:10.1016/S0278-6915(99)00093-9
Keywords: Nutrition · β-Carotene · Pancreatic carcinogenesis · Rat model · Selenium · Vitamins C and E · Alpha tocopherol · Antioxidant · Ascorbic acid · Azaserine · Beta carotene · Glutathione · Selenium · Animal experiment · Animal model · Antioxidant activity · Cancer prevention · Carcinogenesis · Controlled study · Diet supplementation · Male · Nonhuman · Pancreas cancer · Rat · Animals · Antioxidants · Ascorbic Acid · Azaserine · Beta Carotene · Dietary Supplements · Drug Combinations · Male · Pancreatic Neoplasms · Precancerous Conditions · Rats · Rats, Wistar · Selenium · Time Factors · Vitamin E

Abstract

Previously performed short-term (4-month) studies demonstrated that vitamins C and E, β-carotene and selenium modulate growth of early putative preneoplastic acinar lesions induced in rat pancreas by azaserine. The present paper summarizes the results of long-term studies performed with azaserine-treated rats maintained on diets high in either β-carotene, vitamins C and E or selenium. It appeared that rats given a diet high in β-carotene, vitamin C or selenium, but not vitamin E, developed fewer pancreatic tumours than controls. The chemopreventive effects of these micronutrients were most pronounced when β-carotene and/or selenium were given during the promotion phase of the carcinogenic process. Surprisingly, cell proliferation in azaserine-induced preneoplastic acinar lesions was higher in rats given β-carotene and/or selenium via the diet in comparison to controls. It is considered unlikely that any antioxidant alone can be associated with protection against cancer. It is concluded that dietary supplementation of combinations of antioxidants may have practical application in chemoprevention of cancer. Copyright (C) 1999 Elsevier Science Ltd.