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Alcohol, coagulation and fibrinolysis

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Author: Hendriks, H.F.J. · Gaag, M.S. van der
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:Novartis Foundation Symposium, 216, 111-124
Identifier: 234829
Keywords: Nutrition · Animal · Blood · Coronary artery disease · Drinking behavior · Drug effect · Fibrinolysis · Human · Review · Alcohol Drinking · Animals · Coronary Disease · Fibrinolysis · Humans


Despite the solid evidence for thrombosis playing a key role in coronary heart disease (CHD) mortality, identifying specific haemostatic risk factors for CHD has been difficult except for fibrinogen. Excessive alcohol consumption clearly affects platelet function. Moderate alcohol consumption may affect several haemostatic factors, including fibrinogen concentration, platelet aggregability and the fibrinolytic factors tissue-type plasminogen activator and plasminogen activator inhibitor. These changes support the hypothesis that moderate alcohol beneficially affects the haemostatic balance in a way that decreases the risk of CHD mortality.